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Guest: Dr. Michael Schmidt. Topics: Personal spaceflight medicine, Omics, targeted genetic countermeasures. Please direct all comments and questions regarding Space Show programs/guest(s) to the Space Show blog, http://thespaceshow.wordpress.com. Comments and questions should be relevant to the specific Space Show program. Written Transcripts of Space Show programs are a violation of our copyright and are not permitted without prior written consent, even if for your own use. We do not permit the commercial use of Space Show programs or any part thereof, nor do we permit editing, YouTube clips, or clips placed on other private channels & websites. Space Show programs can be quoted, but the quote must be cited or referenced using the proper citation format. Contact The Space Show for further information. In addition, please remember that your Amazon purchases can help support The Space Show/OGLF. See www.onegiantleapfoundation.org/amazon.htm. For those listening to archives using live365.com and rating the programs, please email me as to why you assign a specific rating to the show. This will help me bring better programming to the audience. We welcomed back Dr. Michael Schmidt for updates and more information regarding Personal Spaceflight Medicine. Note that the abstract referenced in the second segment has been uploaded to the blog for this show. During the first segment of our 92 minute program, Dr. Schmidt defined personal spaceflight medicine for us & talked about targeting individuals for specific countermeasures to human factors risks for longer duration spaceflight safety. We talked about artificial gravity and radiation with our listeners asking questions about both fields. Our guest cited several examples to make his point. At one point he talked about the current twin study underway on the year long plus ISS experiment with a Russian cosmonaut as well. Questions were asked about using pharmaceuticals in space, how they might react with different people, and the distribution methods so far which are not great. At one point, Dr. Doug emailed in asking about the use of omics for space travel issues and if in fact the use of omics would reveal even more questions that cannot be answered, ultimately delaying long duration HSF missions even longer than they are delayed now. Don't miss the guest response to Doug's question. Kris emailed in asking about the use of deliberate hypothermia to store Mars bound astronauts, and then another Doug question came in about selecting the best people based on omics for a mission. Near the end of the segment, I asked our guest if he had done work for Mars One. He explained their limited capacity relationship which I assume ended. In the second segment, BJohn asked about the possibility of astronauts sleeping in a small vertical centrifuge. Dr. Rowe called to talk about the issue relating to pharmaceutical use in space. he talked about delivery methods, malabsorption, etc. Later, Dr. Schmidt brought up the damage done from sleep deprivation and showed how this is a potential problem for space missions. Doug emailed in a question about GCRs and radiation, then Dr. Schmidt talked about his new paper on BDNF with his associate Dr. thomas Goodwin, "Protecting Neural Structures and Cognitive Function During Prolonged Space Flight by Targeting The Brain Derived Neurotrophic Factor Molecular Network." We talked about BDNF and spaceflight, exercises, mitigation measures, and more. He referenced Mars simulation, behavioral issues and more. You don't want to miss this discussion. Dr. Schmidt provided us with excellent closing remarks. Please post your comments/questions on TSS blog above. You can reach Dr. Schmidt through me.